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  • br c ncer br Conclus

    2022-05-04


    câncer.
    Conclusão: O local mais comum de carcinoma colorretal é o cólon esquerdo, com 61,97%.
    Houve aumento na detecc¸ ão de novos casos de carcinoma colorretal de 2013 a 2016. Os está-
    e 15,49% dos casos. O padrão histopatológico comum é o adenocarcinoma diferenciado, em
    © 2019 Sociedade Brasileira de Coloproctologia. Publicado por Elsevier Editora Ltda. Este
    e´ um artigo Open Access sob uma licenc¸ a CC BY-NC-ND (http://creativecommons.org/
    Introduction
    Colorectal cancer it most events in the down part of the descending colon, the sigmoid colon, or/and rectum.1 Most cases occur in people aged over five decades.2 Colorectal can-cer usually grows, take a period of 10 to 20 years.3 Bowel cancer inserted from a small fleshy polyp on the colon or rectum. The most kind of polyp is an adenomatous polyp when reach age above fifty.3 About one in four people have at least one bowel polyp.3 About two thirds of all colon and rectal tumors found in the colon and the rest in the rectum.4 Most neoplasms are adenocarcinomas. Colorectal cancer is invasive but metastatic spread may happened before local growth.3 The most site of colon and rectum carcinoma for Suramin is the liver.2 It is second most common cancer in female and third in male, and it being fourth most common cause of cancer death beyond lung, stomach, and liver cancers.5 It is more common in devel-oped than developing countries. Occurrence related to age, with almost 75% of cases occurring in people aged 65 or over. In US and European countries, about 2–8% of cases occur in below forty, whereas in Egypt, Saudi Arabia, Philippines, and Iran recorded rates of 38%, 21%, 17%, and 15–35%, for the same age group.2,4,5
    Methods 
    Duration of study
    The information collected from February 2013 to November 2016.
    Populations
    71 from 1894 patients that found have colorectal cancer that attended.
    Design of study
    Epidemiological, and clinical study involved gender, age, res-idency, site of cancer, family history, past history, year of onset, smoking history, staging and histopathology types are observed.
    Statistical analysis
    The significances via different tests to compares between the epidemiological results.
    Results
    Significant result
    Area of study The prevalence, family history, cancer site, year of man-
    There were significant differences among age groups and histopathological patterns (p < 0.001) (Table 1).
    Un-significant results
    They recorded no significant differences among gender, resi-dency, tobacco habits, alcohol consumption and presentation (p > 0.05 and p > 0.01) (Table 1).
    Discussion
    Because of low socioeconomic status, insufficient screening methods, doubtful early detection, low educational level, errors in diagnosis and unavailability of diagnostic tools, the prevalence was 3.75% which less than expected in compari-son with reports from other countries in the world according to WHO, NIC, NICE and CRUK.1,2,4–7 The percent of cancer were higher in developed countries as US, UK, Australia, Ger-many, France, Italy, Spain, Canada, Japan and Turkey, due to increasing of risky factors as sedentary lifestyle, alcohol con-sumption, cigarette smoking, obesity and meaty food.6–9 In developing and poor cities the ratios different.7 The stud-ies showed high prevalence in Jordan, Iran, Egypt and Saudi Arabia but reptiles low in African countries.8 The most age groups affected in this study were 40–60 years, as 41–50 and 51–60, in 23.94% and 30.99% respectively. This recorded in the most studies conducted worldwide.1–3,7
    About gender and residency, there were no significant rela-tionship and that belong to the nature of cancer, which not related to sex or living areas. Cigarette smoking and alcohol consumption play risk role, but there were no significant pre-sented or obtained. While in many studies in other countries showed a strong relation between cancer and tobacco habit and alcohol intake.6,7 In America, Europa and Asia, the family history of colorectal cancer, and family history of other can-cer, if positive, the incidence will increase,3,6,7 which is 42.25% in this study. The most common site of carcinoma was left colon, which presented in 61.97% and this due to anatomic circumferential. According to Giovannucci and Wu, the most common site is the sigmoid 25% followed by the rectum 21%, cecum 20%, rectosigmoid junction 20%, transverse colon 15%, ascending colon 10%.6 This explain by many reasons as inaccuracy of investigation methods or neglected accu-rate results of colonoscopy. Because off increase awareness among national people with increased of buildup of oncol-ogy centers in our countries, we obtained slight increase in new cases detection of colorectal carcinoma from 2013 to 2016. The viable symptoms and sings found in different proportions of no significant. On staging, the most common stages were advance as IIIA, IIIB, IIIC and IV in 12.67%, 16.90%, 19.72%, 15.49% respectively. These results were like other studies con-ducted in Asia, Europa and South America.5,7–9 Those due to late diagnosis, un-availability of screening tools and decreased awareness. Another studies in developed countries as US, UK, Australia, Canada, New Zealand, Japan, South Korea and China, determination of excite cancer in early stages due to increase screening facilities, increase awareness about it and available of methods of early detection.6–9 The most common histopathological pattern was adenocarcinoma (well, poor,